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Chem Commun (Camb). 2019 May 28;55(43):5994-5997. doi: 10.1039/c9cc02610j. Epub 2019 May 3.

Quartz crystal microbalance for telomerase sensing based on gold nanoparticle induced signal amplification.

Author information

1
Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. weiw@seu.edu.cn.
2
Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450001, China.
3
College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, P. R. China.

Abstract

A novel circulating-flow quartz crystal microbalance (QCM) biosensing method has been established to detect telomerase. Oligonucleotide-functionalized gold nanoparticles (GNPs-cDNA) have been used to amplify the frequency change, which enable this QCM to be a sensitive biosensor for telomerase activity detection. The detection limit was as low as 37 cells per mL. The assay platform exhibited excellent selectivity.

PMID:
31049531
DOI:
10.1039/c9cc02610j
[Indexed for MEDLINE]

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