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Psychopharmacology (Berl). 1987;91(3):285-7.

Fluoxetine suppresses palatability-induced ingestion.


Non-deprived rats were allowed 1-h access to a range of saccharin solutions from 0.001 to 0.1 M Na saccharin. Compared to a group of rats drinking tap water, the rats drinking the saccharin solutions ingested a great deal more fluid, with as much as 24-30 ml consumed of the 0.01 M concentration, compared to 3-5 ml in controls. Fluoxetine (IP) decreased this palatability-induced excessive consumption in a dose-related manner. Effects of 10 mg/kg fluoxetine were apparent for 48 h after injection. This effect on palatability-induced ingestion may relate to previously reported effects of fluoxetine on food consumption.

[Indexed for MEDLINE]

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