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Curr Opin Behav Sci. 2019 Aug;28:44-50. doi: 10.1016/j.cobeha.2019.01.009. Epub 2019 Feb 26.

The interplay among psychological distress, the immune system, and brain tumor patient outcomes.

Author information

1
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.
2
Department of Preventative Medicine-Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.
3
Department of Psychology, University of Miami, United States.
4
Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.
5
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.

Abstract

A malignant brain tumor diagnosis is often accompanied with intense feelings and can be associated with psychosocial conditions including depression, anxiety, and/or increased distress levels. Previous work has highlighted the impact of uncontrolled psychological distress among brain tumor patients. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes.

KEYWORDS:

Psychosocial; biobehavioral; glioblastoma; glioma; immunosuppression

PMID:
31049368
PMCID:
PMC6487487
[Available on 2020-08-01]
DOI:
10.1016/j.cobeha.2019.01.009

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