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Science. 2019 May 3;364(6439):458-464. doi: 10.1126/science.aav9750.

Multivascular networks and functional intravascular topologies within biocompatible hydrogels.

Author information

1
Department of Bioengineering, Rice University, Houston, TX 77005, USA.
2
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
3
Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.
4
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
5
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
6
Nervous System, Somerville, MA 02143, USA.
7
Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA.
8
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. ksteve@uw.edu jmil@rice.edu.
9
Department of Bioengineering, Rice University, Houston, TX 77005, USA. ksteve@uw.edu jmil@rice.edu.
#
Contributed equally

Abstract

Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation.

PMID:
31048486
DOI:
10.1126/science.aav9750

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