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Atherosclerosis. 2019 Jun;285:79-86. doi: 10.1016/j.atherosclerosis.2019.04.215. Epub 2019 Apr 13.

Biomarkers of mineral metabolism and progression of aortic valve and mitral annular calcification: The Multi-Ethnic Study of Atherosclerosis.

Author information

1
Department of Medicine, Division of Cardiology, Jack D. Weiler Hospital, Montefiore Medical Center, Bronx, NY, USA.
2
Department of Medicine, Division of Cardiology, Jack D. Weiler Hospital, Montefiore Medical Center, Bronx, NY, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
3
Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.
4
Department of Medicine, Division of Nephrology-Hypertension, University of California, San Diego and Veterans' Affairs Medical Center, San Diego, La Jolla, CA, USA.
5
Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.
6
Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
7
Department of Medicine, Division of Cardiology, McGill University Health Center, Montreal, QC, Canada.
8
New York Academy of Medicine, New York, NY, USA.
9
Department of Medicine, Division of Cardiology, David Geffen School of Medicine at the University of California, CA, USA.
10
Cardiology Section, San Francisco Veterans Affairs Health Care System and Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. Electronic address: jorge.kizer@ucsf.edu.

Abstract

BACKGROUND AND AIMS:

Previous research has implicated dysregulation of phosphate metabolism and calcium-phosphate solubilization in cardiovascular calcification, but epidemiologic studies evaluating longitudinal associations with valvular or annular calcification by computed tomography (CT), a highly sensitive imaging modality, are lacking. Our primary aim was to investigate the associations of mineral biomarkers with incidence and progression of aortic valve calcification (AVC) and mitral annular calcification (MAC).

METHODS:

We evaluated the associations of serum FGF-23 (n = 6547 participants), phosphate (n = 6547), and fetuin-A (n = 2550) measured at baseline in the community-based Multi-Ethnic Study of Atherosclerosis with AVC and MAC on CT performed at baseline and at a median of 2.4 (1.6, 3.1) years later. We used linear mixed-effects models to account simultaneously for prevalence, incidence and progression of AVC and MAC.

RESULTS:

After adjustment for demographic and clinical characteristics, a significant association was documented for FGF-23 with accelerated annual progression of MAC (2.83 Agatston units (AU), 95% CI = 0.49, 5.17 AU, per standard deviation (18.46 pg/mL) of FGF-23), but this was not seen for phosphate or fetuin-A. None of these biomarkers was associated with accelerated annual progression of AVC.

CONCLUSIONS:

This study provides evidence relating serum FGF-23 to accelerated annual MAC progression. Whether this mineral regulator is a risk marker or is involved in pathogenesis merits further investigation.

KEYWORDS:

Fetuin-A; Fibroblast growth factor; Metabolism; Mineral; Valve

PMID:
31048102
PMCID:
PMC6536341
[Available on 2020-06-01]
DOI:
10.1016/j.atherosclerosis.2019.04.215

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