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Neuron. 2019 Jun 5;102(5):1076-1087.e8. doi: 10.1016/j.neuron.2019.03.043. Epub 2019 Apr 29.

Causal Inference in the Multisensory Brain.

Author information

1
Department of Experimental Psychology, University of Oxford, Walton Street, Oxford OX2 6AE, UK. Electronic address: yinan.cao@psy.ox.ac.uk.
2
Department of Experimental Psychology, University of Oxford, Walton Street, Oxford OX2 6AE, UK.
3
Department for Cognitive Neuroscience and Cognitive Interaction Technology-Center of Excellence, Bielefeld University, 33615 Bielefeld, Germany.
4
Institut de Neurosciences de la Timone UMR 7289 Centre National de la Recherche Scientifique and Aix-Marseille Université, Marseille, France; Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB, UK.
5
Department for Cognitive Neuroscience and Cognitive Interaction Technology-Center of Excellence, Bielefeld University, 33615 Bielefeld, Germany. Electronic address: christoph.kayser@uni-bielefeld.de.

Abstract

When combining information across different senses, humans need to flexibly select cues of a common origin while avoiding distraction from irrelevant inputs. The brain could solve this challenge using a hierarchical principle by deriving rapidly a fused sensory estimate for computational expediency and, later and if required, filtering out irrelevant signals based on the inferred sensory cause(s). Analyzing time- and source-resolved human magnetoencephalographic data, we unveil a systematic spatiotemporal cascade of the relevant computations, starting with early segregated unisensory representations, continuing with sensory fusion in parietal-temporal regions, and culminating as causal inference in the frontal lobe. Our results reconcile previous computational accounts of multisensory perception by showing that prefrontal cortex guides flexible integrative behavior based on candidate representations established in sensory and association cortices, thereby framing multisensory integration in the generalized context of adaptive behavior.

KEYWORDS:

MEG; causal inference; crossmodal; decision making; flexible behavior; magnetoencephalography; parietal cortex; representational similarity analysis; sensory fusion; structure inference; ventrolateral prefrontal cortex

PMID:
31047778
DOI:
10.1016/j.neuron.2019.03.043
[Indexed for MEDLINE]

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