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Neurol Sci. 2019 May 2. doi: 10.1007/s10072-019-03886-4. [Epub ahead of print]

Influence of chronotype on migraine characteristics.

Author information

1
Neurological Clinic, Marche Polytechnic University, Via Conca 1, 60100, Ancona, Italy. viticchi.g@gmail.com.
2
Internal and Subintensive Medicine, Ospedali Riuniti, Ancona, Italy.
3
Neurology Unit, Campus Bio-Medico University, Rome, Italy.
4
Neurological Clinic, Marche Polytechnic University, Via Conca 1, 60100, Ancona, Italy.

Abstract

BACKGROUND:

The aim of this study was to investigate chronotype in migraine patients and possible influences on the clinical expression of the disease.

METHODS:

During a one-year period, all consecutive patients admitted to two third-level headache centres with a new diagnosis of migraine were enrolled in a cross-sectional study. All subjects were submitted to the Morningness-Eveningness Questionnaire (MEQ-SA) and then classified in five different categories, from late to early-rising chronotype. Differences and trends among MEQ-SA categories and years from migraine onset, attacks' intensity and frequency were analysed first with analysis of variance, then with a multivariate/generalized linear model.

RESULTS:

One hundred seventy one migraine patients were included. Early-rising patients showed a lower migraine attacks frequency and longer disease duration with respect to late-rising patients. The categorical variable containing the five circadian types was able to identify a significantly different trend both for the monthly attacks frequency and for the disease duration (p < 0.0001 and p < 0.0001, respectively, analysis of variance). The results were also confirmed after correction for main influencing variables (multivariate/generalized linear model). The intensity of migraine attacks was not influenced by chronotype.

CONCLUSIONS:

According to the results of the present study, chronotype seems to influence number and duration of migraine attacks. Although sleep-wake cycle is a well-recognized factor able to influence thalamic-cortical synchronization, it usually does not receive appropriate consideration during migraine patients' assessment.

KEYWORDS:

Circadian rhythm; Headache; Sleep; Sleep–wake cycle

PMID:
31044321
DOI:
10.1007/s10072-019-03886-4

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