Abstract
Cisplatin is a commonly used drug in the treatment of solid tumors and its application is associated with testicular toxicity. The effect of candesartan in cisplatin-induced testicular toxicity and its fundamental mechanism of action were investigated. Candesartan had certainly repaired the testicular injury and ameliorated both biochemical and histopathological changes. Candesartan mitigated the gonadotoxicity induced by cisplatin via antioxidative, anti-inflammatory, and antiapoptotic actions.
Keywords:
Cisplatin; apoptosis; candesartan; oxidative stress index; testicular toxicity.
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use*
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Antineoplastic Agents / toxicity*
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Apoptosis
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Benzimidazoles / pharmacology
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Benzimidazoles / therapeutic use*
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Biphenyl Compounds
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Cisplatin / toxicity*
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Male
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Necrosis
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Oxidative Stress
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Rats
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Rats, Sprague-Dawley
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Testicular Diseases / drug therapy*
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Testicular Diseases / etiology
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Testicular Diseases / prevention & control
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Testis / drug effects*
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Testis / metabolism
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Tetrazoles / pharmacology
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Tetrazoles / therapeutic use*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Benzimidazoles
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Biphenyl Compounds
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Tetrazoles
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Tumor Necrosis Factor-alpha
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Cisplatin
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candesartan