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Dermatol Ther (Heidelb). 2019 Jun;9(2):321-326. doi: 10.1007/s13555-019-0298-x. Epub 2019 Apr 30.

The Scar Bane, Without the Pain: A New Approach in the Treatment of Elevated Scars: Thermomechanical Delivery of Topical Triamcinolone Acetonide and 5-Fluorouracil.

Author information

1
Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
2
Dr. Artzi Treatment and Research Center, Tel Aviv, Israel.
3
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
4
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. or.friedman@gmail.com.
5
The Plastic Reconstructive Surgery Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. or.friedman@gmail.com.

Abstract

INTRODUCTION:

Keloids are challenging to treat due to their inadequate response to treatment and high recurrence rate. Intralesional triamcinolone acetonide (TAC) injection with or without 5-fluorouracil (5FU) is considered the first-line treatment for keloids. Three significant disadvantages of intralesional injections are the pain associated with the procedure, the uneven topography, and epidermal atrophy. Fractionated ablative carbon dioxide (CO2) laser-assisted drug delivery (LADD) of the topical solution can help facilitate transdermal drug delivery and shows promise in scar remodeling. This study examined the use of a thermomechanical device (Tixel, Novoxel) to facilitate the transdermal delivery of TAC and 5-FU in the treatment of keloid scars.

METHODS:

Seven patients each received eight topical thermal ablations, with one ablation performed every 2-3 weeks. TAC and 5FU were applied after each ablation. Outcomes were evaluated using the Vancouver Scar Scale (VSS), and pain was assessed using the Visual Analog Scale (VAS).

RESULTS:

Mean keloid VSS reduced from 8.6 ± 1.2 to 5 ± 2.7 after the eight treatments. Mean treatment pain VAS score was 2.4 ± 0.7. Patients rated their satisfaction level as moderate-high. No severe adverse reactions were noted.

CONCLUSION:

Thermomechanical drug delivery of TAC and 5-FU is safe and effective. This is a promising option for the treatment of keloid scars, particularly in the pediatric population.

KEYWORDS:

Fluorouracil; Fractional skin ablation; Keloid; Percutaneous permeating; Resurfacing; Scar; Tixel; Transdermal drug delivery; Triamcinolone

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