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J Nanosci Nanotechnol. 2019 Nov 1;19(11):6956-6960. doi: 10.1166/jnn.2019.16419.

A Clinical Study of Early Intervention with Coralline Hydroxyapatite on Fresh Extraction Sockets.

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Jiangxi Cancer Hospital, Nanchang 330029, China.
Affiliated Stomatological Hospital of Jiujiang University, Jiujiang 332000, China.
First Affiliated Hospital of Nanchang University, Nanchang 330006, China.


To clinically, histologically and radiologically evaluate the effects of early intervention on fresh extraction sockets, 30 patients were selected and assigned evenly into group A (blood clot) and group B (coralline hydroxyapatite). All participants underwent clinical examination. Oral plaster casts and panoramic radiographs were undertaken before tooth extraction and at 3-4 months after socket grafting. A 6-8 mm sample of longitudinal bone core was obtained using a 2 mm diameter trephine 3-4 month's post-operatively. Group A had a greater decrease in interdental papilla height, which was about 2-3 times more than that of group B (P >0.001). The buccal-lingual alveolar ridge width also absorbed more in group A (P >0.001). Radiological findings were similar. Group B had less new bone formation (P >0.001), and the residual rate was a little high. There was no statistical difference between the two groups in terms of new bone formation rating grade. Clinical, histological and radiological tissue differences were observed between sockets with and without biomaterial grafts 3-4 months after surgery. This indicates that early intervention of extraction sockets is clinically advantageous.


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