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Cancer Genet Cytogenet. 1987 May;26(1):157-63.

Cytogenetic clones in a recurrent neurofibroma.

Abstract

Chromosome studies were performed on a plexiform neurofibroma arising in a probable von Recklinghausen's disease patient, who also showed a de novo constitutional reciprocal translocation, t(1;22)(p32;q11). Banding analysis of the metaphases obtained from two primary cultures in vitro showed the presence of five cytogenetic clones, characterized by different chromosomal rearrangements. In addition to t(1;22), marker chromosomes involved pairs 1, 2, 3, 5, 8, 9, 10, 12, 16, and X. These findings suggest a possible polyclonal evolution in this neurofibroma.

PMID:
3103906
DOI:
10.1016/0165-4608(87)90142-7
[Indexed for MEDLINE]

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