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Bioinformatics. 2019 Apr 30. pii: btz297. doi: 10.1093/bioinformatics/btz297. [Epub ahead of print]

Adaptive boosting-based computational model for predicting potential miRNA-disease associations.

Author information

1
School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China.

Abstract

MOTIVATION:

Recent studies have shown that microRNAs (miRNAs) play a critical part in several biological processes and dysregulation of miRNAs is related with numerous complex human diseases. Thus, in-depth research of miRNAs and their association with human diseases can help us solve many problems.

RESULTS:

Due to the high cost of traditional experimental methods, revealing disease-related miRNAs through computational models is a more economical and efficient way. Considering the disadvantages of previous models, in this paper, we developed Adaptive Boosting for MiRNA-Disease Association prediction (ABMDA) to predict potential associations between diseases and miRNAs. We balanced the positive and negative samples by performing random sampling based on k-means clustering on negative samples, whose process was quick and easy, and our model had higher efficiency and scalability for large data sets than previous methods. As a boosting technology, ABMDA was able to improve the accuracy of given learning algorithm by integrating weak classifiers that could score samples to form a strong classifier based on corresponding weights. Here, we used decision tree as our weak classifier. As a result, the AUC of global and local leave-one-out cross validation reached 0.9170 and 0.8220, respectively. What's more, the mean and the standard deviation of AUCs achieved 0.9023 and 0.0016 respectively in 5-fold cross validation. Besides, in the case studies of three important human cancers, 49, 50 and 50 out of the top 50 predicted miRNAs for Colon Neoplasms, Hepatocellular Carcinoma and Breast Neoplasms were confirmed by the databases and experimental literatures.

AVAILABILITY:

The code and dataset of ABMDA are freely available at https://github.com/githubcode007/ABMDA.

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

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