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AIDS Res. 1986 Dec;2 Suppl 1:S147-9.

Detection of antibody to LAV/HTLV-III in sera from hemophiliacs in China.


Using ELISA, Western blots and immunofluorescence techniques, we identified seropositivity for lymphadenopathy-associated virus/human lymphotropic virus-III (LAV/HTLV-III) in 4 of 18 hemophiliacs and 1 AIDS patient. The four seropositive patients had received factor VIII prepared by Armour Company. The hemophiliacs are all asymptomatic. Given this documentation of introduction of LAV/HTLV-III into China, a national surveillance program is underway.


The detection of human immunodeficiency virus (HIV) in hemophiliacs treated with factor VIII has prompted the Government of China to institute a national surveillance program. An earlier survey of 310 healthy individuals and leukemia patients from 8 provinces failed to yield any sera positive for antibodies to HIV. However, given the documented high seroprevalence rate among hemophiliacs, the sera of 28 Chinese hemophiliacs and 1 acquired immunodeficiency syndrome (AIDS) patient were analyzed by enzyme-linked immunosorbent assay (ELISA). Antibodies to HIV were detected in the AIDS patient and in 4 of the hemophiliacs. All 4 of the seropositive cases were from a group of 18 hemophiliacs who had received factor VIII produced by the US-based Armour Company. This suggests that HIV infection was transmitted to China from the US via blood products at a frequency of 22%. At the time of the study, all 4 seropositive hemophiliacs were asymptomatic.

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