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Acta Otolaryngol. 2019 Jun;139(6):529-535. doi: 10.1080/00016489.2019.1605454. Epub 2019 Apr 29.

Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery.

Author information

1
a Department of Otorhinolaryngology, Faculty of Medicine, Military Medical Academy , University of Defense , Belgrade , Serbia.
2
b Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy , University in Belgrade , Belgrade , Serbia.
3
c Clinical Center of Serbia, School of Medicine , University in Belgrade , Belgrade , Serbia.
4
d ENT Hospital "Dr. Zutic" , Belgrade , Serbia.
5
e Institute for Pharmacy, Faculty of Medicine, Military Medical Academy , University of Defense , Belgrade , Serbia.
6
f ENT Department , Lovisenberg Diakonale Hospital , Oslo , Norway.

Abstract

BACKGROUND:

Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs).

AIM/OBJECTIVE:

To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS).

MATERIAL AND METHODS:

This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal.

RESULTS:

We found significantly lower total symptom score (TSS) during the 7th (p = .009), 14th (p = .003), 21st (p < .001) and the 28th day (p = .001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water.

CONCLUSION AND SIGNIFICANCE:

Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.

KEYWORDS:

Aspirin; nasal polyps; nasal surgical procedures; postoperative care; sinusitis

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