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Nutrients. 2019 Apr 26;11(5). pii: E954. doi: 10.3390/nu11050954.

Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Older Males.

Author information

1
VasoActive Research Group, School of Health and Sport Sciences, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia. mwalker@usc.edu.au.
2
VasoActive Research Group, School of Health and Sport Sciences, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia. tom.bailey@uq.edu.au.
3
School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, QLD 4072, Australia. tom.bailey@uq.edu.au.
4
Institute for Health and Sport, College of Sport and Exercise Science, Victoria University, Melbourne, VIC 3031, Australia. luke.mcilvenna@live.vu.edu.au.
5
Institute for Health and Sport, College of Sport and Exercise Science, Victoria University, Melbourne, VIC 3031, Australia. ja6af@virginia.edu.
6
Department of Kinesiology, University of Virginia, Charlottesville, VA 22903, USA. ja6af@virginia.edu.
7
School of Sport Sciences, Exercise and Health, University of Western Australia, West Perth, WA 6872, Australia. danny.green@uwa.edu.au.
8
VasoActive Research Group, School of Health and Sport Sciences, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia. caskew@usc.edu.au.
9
Sunshine Coast Health Institute, Sunshine Coast Hospital and Health Service, Birtinya, QLD 4575, Australia. caskew@usc.edu.au.

Abstract

Aging is often associated with reduced leg blood flow, increased arterial stiffness, and endothelial dysfunction, all of which are related to declining nitric oxide (NO) bioavailability. Flow mediated dilatation (FMD) and passive leg movement (PLM) hyperaemia are two techniques used to measure NO-dependent vascular function. We hypothesised that acute dietary nitrate (NO3-) supplementation would improve NO bioavailability, leg FMD, and PLM hyperaemia. Fifteen healthy older men (69 ± 4 years) attended two experiment sessions and consumed either 140 mL of concentrated beetroot juice (800 mg NO3-) or placebo (NO3--depleted beetroot juice) in a randomised, double blind, cross-over design study. Plasma nitrite (NO2-) and NO3-, blood pressure (BP), augmentation index (AIx75), pulse wave velocity (PWV), FMD of the superficial femoral artery, and PLM hyperaemia were measured immediately before and 2.5 h after consuming NO3- and placebo. Placebo had no effect but NO3- led to an 8.6-fold increase in plasma NO2-, which was accompanied by an increase in FMD (NO3-: +1.18 ± 0.94% vs. placebo: 0.23 ± 1.13%, p = 0.002), and a reduction in AIx75 (NO3-: -8.7 ± 11.6% vs. placebo: -4.6 ± 5.5%, p = 0.027). PLM hyperaemia, BP, and PWV were unchanged during both trials. This study showed that a dose of dietary NO3- improved NO bioavailability and enhanced endothelial function as measured by femoral artery FMD. These findings provide insight into the specific central and peripheral vascular responses to dietary NO3- supplementation in older adults.

KEYWORDS:

arterial stiffness; beetroot juice; blood flow; cardiovascular risk; endothelial function; inorganic nitrate; nitric oxide

PMID:
31035478
PMCID:
PMC6566150
DOI:
10.3390/nu11050954
[Indexed for MEDLINE]
Free PMC Article

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