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Pediatr Infect Dis J. 2019 Jul;38(7):727-730. doi: 10.1097/INF.0000000000002357.

Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk.

Author information

1
From the Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2
Department of Obstetrics and Prenatal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
3
First Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
4
Department of Paediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Düsseldorf, Germany.
5
Department of Obstetrics and Gynaecology, Heinrich Heine University, Düsseldorf, Germany.
6
Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, Düsseldorf, Germany.
7
Ifi-Institute for Interdisciplinary Medicine, Hamburg, Germany.
8
Neonatology Unit at Asclepios Hospital Hamburg-Barmbek, Hamburg, Germany.
9
Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.
10
Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's, University of London, United Kingdom.

Abstract

Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.

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