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Hematol Oncol Clin North Am. 2019 Jun;33(3):393-408. doi: 10.1016/j.hoc.2019.01.006. Epub 2019 Mar 29.

Disorders of Iron Metabolism: New Diagnostic and Treatment Approaches to Iron Deficiency.

Author information

1
Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children's Cancer and Hematology Centers, 6701 Fannin Street, Suite 1580, Houston, TX 77030, USA. Electronic address: jmpowers@texaschildrens.org.
2
Pediatric Hematology-Oncology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, H3.104A, Dallas, TX 75390-9063, USA.

Abstract

Iron deficiency anemia is the leading cause of anemia worldwide and affects many young children and adolescent girls in the United States. Its signs and symptoms are subtle despite significant clinical effects. Iron deficiency anemia is diagnosed clinically by the presence of risk factors and microcytic anemia. Improvement following a trial of oral iron therapy is confirmative. An array of iron laboratory tests is available with variable indications. Clinical trial and iron absorption data support a shift to lower-dose oral iron therapy. Intravenous iron should be considered in children who fail oral iron or who have more complex disorders.

KEYWORDS:

Ferritin; Hepcidin; Intravenous; Iron; Oral; Therapy

PMID:
31030809
DOI:
10.1016/j.hoc.2019.01.006

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