Format

Send to

Choose Destination
Nutrients. 2019 Apr 25;11(4). pii: E930. doi: 10.3390/nu11040930.

Local In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults.

Author information

1
College of Health Sciences, University of Kentucky, Lexington, KY 40536, USA. dth225@uky.edu.
2
Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA. dave.schnell@uky.edu.
3
Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA. mre226@g.uky.edu.
4
Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536, USA. mingjun.zhao@uky.edu.
5
Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA. hideat.abraha@gmail.com.
6
Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA. Danielle.Jones@uky.edu.
7
Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536, USA. howard.brim@uky.edu.
8
Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536, USA. gyu2@uky.edu.

Abstract

Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL). Male and female subjects aged 60-80 years with a BMI ranging from 18.5-34.9 and vitamin D status of ≤32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 × 2 factorial design. Cholecalciferol (Vitamin D3) (10,000 IU × 5 days/week) or placebo was provided for 13 weeks and treadmill aerobic training during week 13. Gastrocnemius IMCL and EMCL were measured with magnetic resonance spectroscopy (MRS) and MRI. Hybrid near-infrared diffuse correlation spectroscopy measured hemodynamics. Group differences in IMCL were observed when controlling for baseline IMCL (p = 0.049). DAT was the only group to reduce IMCL from baseline, while a mean increase was observed in all other groups combined (p = 0.008). IMCL reduction and the corresponding increase in rVO2 at study end (p = 0.011) were unique to DAT. Vitamin D, when combined with exercise, may potentiate the metabolic benefits of exercise by reducing IMCL and increasing tissue-level VO2 in healthy, older adults.

KEYWORDS:

IMCL; metabolic function; sarcopenia; skeletal muscle; vitamin D

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center