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Regen Med. 2019 May;14(4):331-343. doi: 10.2217/rme-2018-0146. Epub 2019 Apr 26.

Therapeutic targeting of gastrointestinal cancer stem cells.

Author information

1
Departments of Surgery, Sidney, 1020 Locust St, JAH368, Philadelphia, PA 19107, USA.
2
Pharmacology & Experimental Therapeutics, Sidney, 1020 Locust St, JAH368, Philadelphia, PA 19107, USA.

Abstract

Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer.

KEYWORDS:

cancer stem cells; chemoresistance; gastrointestinal cancer; immunotherapy; radioresistance; targeted therapies

PMID:
31025613
DOI:
10.2217/rme-2018-0146

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