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Pediatr Dermatol. 2019 May;36(3):274-282. doi: 10.1111/pde.13827. Epub 2019 Apr 25.

A review of cutaneous hypersensitivity reactions in infants: From common to concerning.

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University of Chicago Pritzker School of Medicine, Chicago, Illinois.
Section of Dermatology, Department of Medicine and Pediatrics, University of Chicago, Chicago, Illinois.


Cutaneous hypersensitivity reactions in infants present in a variety of patterns. These skin eruptions can be dramatic, causing alarm in parents and medical personnel. Many of these syndromes have overlapping features, which adds to the confusion and uncertainty regarding diagnosis and management. This review discusses the spectrum of hypersensitivity responses with a focus on their presentation in infants. The clinical findings, pathophysiology, histopathology, management, and complications of these conditions will be reviewed.


Henoch-Schönlein purpura; Kawasaki disease; Stevens-Johnson syndrome; Sweet syndrome; acute annular urticaria; acute generalized exanthematous pustulosis; acute hemorrhagic edema of infancy; annular erythema of infancy; childhood hypersensitivity reaction; drug reaction with eosinophilia and systemic symptoms; drug-induced hypersensitivity syndrome; eosinophilic cellulitis; erythema multiforme; serum sickness-like reaction; toxic epidermal necrolysis


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