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J Clin Exp Hepatol. 2019 Mar-Apr;9(2):233-244. doi: 10.1016/j.jceh.2018.05.002. Epub 2018 May 17.

Systems Challenges of Hepatic Carcinomas: A Review.

Author information

1
Department of Biochemistry, Osmania University, Hyderabad 500007, TG, India.
2
Bioclues.org.
3
Department of Genetics and Biotechnology, Osmania University, Hyderabad 500007, TG, India.
4
Patient MD, Chicago, IL 60640-5710, United States.
5
Instituto Peruano de Energía Nuclear, Avenida Canadá 1470, Lima, Peru.
6
Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle 302001, RJ, India.

Abstract

Hepatocellular Carcinoma (HCC) is ubiquitous in its prevalence in most of the developing countries. In the era of systems biology, multi-omics has evinced an extensive approach to define the underlying mechanism of disease progression. HCC is a multifactorial disease and the investigation of progression of liver cirrhosis becomes much extensive with cultivating omics approaches. We have performed a comprehensive review about such challenges in multi-omics approaches that are concerned to identify the immunological, genetics and epidemiological factors associated with HCC.

KEYWORDS:

HBV, Hepatitis B Virus; HCC, Hepatocellular Carcinoma; HCV, Hepatitis B Virus; NAFLD, Non-Alcoholic Fatty Liver Disease; hepatocellular carcinoma; immunomodulators; signaling pathways; systems biology

PMID:
31024206
PMCID:
PMC6477144
[Available on 2020-03-01]
DOI:
10.1016/j.jceh.2018.05.002

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