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Int J Stem Cells. 2019 Jul 31;12(2):340-346. doi: 10.15283/ijsc18123.

Hybrid Nanofiber Scaffold-Based Direct Conversion of Neural Precursor Cells/Dopamine Neurons.

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Research and Development Center, Jeil Pharmaceutical Company, Yongin, Korea.
Graduate School of Biomedical Science & Engineering, Hanyang University, Seoul, Korea.
School of Mechanical & Aerospace Engineering, Seoul National University, Seoul, Korea.
Center for Food and Bioconvergence, Department of Food Science and Biotechnology, Seoul National University, Seoul, Korea.
Research Institute of Advanced Materials, Seoul National University, Seoul, Korea.
Department of Microbiology, College of Medicine, Hanyang University, Seoul, Korea.


The concept of cellular reprogramming was developed to generate induced neural precursor cells (iNPCs)/dopaminergic (iDA) neurons using diverse approaches. Here, we investigated the effects of various nanoscale scaffolds (fiber, dot, and line) on iNPC/iDA differentiation by direct reprogramming. The generation and maturation of iDA neurons (microtubule-associated protein 2-positive and tyrosine hydroxylase-positive) and iNPCs (NESTIN-positive and SOX2-positive) increased on fiber and dot scaffolds as compared to that of the flat (control) scaffold. This study demonstrates that nanotopographical environments are suitable for direct differentiation methods and may improve the differentiation efficiency.


Direct conversion; Hybrid nanofiber; Neural precursor; iNPC

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