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Curr Opin Infect Dis. 2019 Jun;32(3):196-203. doi: 10.1097/QCO.0000000000000540.

Immune memory characteristics of innate lymphoid cells.

Author information

1
Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES).
2
Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases.
3
Genomics & Immunoregulation, LIMES Institute, University of Bonn, Bonn, Germany.
4
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.

Abstract

PURPOSE OF REVIEW:

Immune memory is essential for host defense against invaders and it is also used as a basis for vaccine development. For these reasons, it is crucial to understand its molecular basis. In this review, we describe recent findings on memory characteristics of innate-like lymphocytes and its contribution to host protection.(Figure is included in full-text article.) RECENT FINDINGS: In addition to adaptive immune cells, innate cells are also able to mount memory responses through a process called 'trained immunity.' Importantly, the lymphoid lineage is not restricted to cells carrying specific T-cell or B-cell receptors, but include cells with germline-encoded receptors. Recent studies show that these innate-like lymphocytes are able to generate efficient recall responses to reinfection. In different circumstances and depending on the cell type, innate-like lymphocyte memory can be antigen-specific or unspecific. Epigenetic changes accompany the generation of memory in these cells, but are still poorly defined.

SUMMARY:

Immune memory is not restricted to antigen-specific cells, but also encompass different populations of innate immune cells. Innate-like lymphocytes embrace features of both innate and adaptive immune memory, and thus bridge adaptive and innate immune characteristics.

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