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Vet Comp Oncol. 2019 Sep;17(3):407-412. doi: 10.1111/vco.12485. Epub 2019 Jun 2.

Synthetic microRNA-205 exhibited tumour suppression in spontaneous canine malignant melanoma by intratumoral injection.

Author information

1
Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Gifu University, Gifu, Japan.
2
Laboratory of Veterinary Radiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan.
3
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
4
Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan.
5
Department of Applied Chemistry, Faculty of Engineering, Aichi Institute of Technology, Toyota, Aichi, Japan.

Abstract

MicroRNAs (miRNA) are small, noncoding RNA molecules consisting of 18 to 25 nucleotides. Malignant melanomas (MMs) are one of the most common malignancies in both dogs and humans. We previously reported that chemically modified synthetic miRNA-205 (miR-205BP/S3) inhibits melanoma growth in vitro and in vivo. The present study aimed to evaluate the efficacy of intratumoral administration of synthetic miR-205 for spontaneous CMMs and to evaluate its potential as systemic therapy. Ten dogs with various stages of MM were treated with miR-205BP/S3 injected into tumours. Adverse effects (AEs) were assessed in accordance with the Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE) v1.1 guidelines. Five cases attained complete remission (CR), three attained stable disease (SD), and two cases displayed characteristics of progressive disease (PD). In all cases, no changes were observed in the blood parameters upon miRNA administration, and miR-205BP/S3 administration did not yield any side effects. The present results suggest that intratumoral administration of miR-205BP/S3 is a potentially applicable treatment for canine melanoma.

KEYWORDS:

canine; melanoma; microRNA; oncology; tumour

PMID:
31020761
DOI:
10.1111/vco.12485
[Indexed for MEDLINE]

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