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Cureus. 2019 Feb 14;11(2):e4074. doi: 10.7759/cureus.4074.

Benign Granular Cell Tumor of the Cecum.

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Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.
Pathology, University of Central Florida College of Medicine, Orlando, USA.
Pathology, Orlando Veterans Affairs Medical Center, Orlando, USA.


Granular cell tumors (GCT) are usually benign, soft tissue tumors that are mostly found in the oral cavity, skin, and subcutaneous tissue. GCTs in the gastrointestinal (GI) tract are mainly located in the esophagus. A 63-year-old male was referred to the gastroenterology clinic for a major complaint of six months of painless rectal bleeding. Laboratory results showed mild macrocytic anemia. He denied any prior colonoscopies and hence, a lower endoscopic procedure was done. The colonoscopy showed multiple polyps, one of them located at the cecum. The cecal polyp showed polygonal cells with abundant eosinophilic infiltration and S100 stain positive. This confirmed a diagnosis of GCT. GCTs are thought to be derived from the neural tissue (Schwann cells). This entity is usually asymptomatic; however, tumors located at the lower GI tract can present with hematochezia. Only 2% of GCTs follow a malignant course, with associated poor prognosis.  This case is being presented because of its asymptomatic nature. It is important to monitor these lesions in order to recognize early signs/symptoms concerning for malignancy.


granular cell tumor; rectum

Conflict of interest statement

The authors have declared that no competing interests exist.

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