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Nutrients. 2019 Apr 23;11(4). pii: E906. doi: 10.3390/nu11040906.

Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.

Author information

1
Department of Bioscience and Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Korea. spandanakopalli@gmail.com.
2
Department of Integrated Biosciences, College of Biomedical & Health Science, Konkuk University, Chungju 27381, Korea. chakm89@kku.ac.kr.
3
Department of Integrated Biosciences, College of Biomedical & Health Science, Konkuk University, Chungju 27381, Korea. lyswo3@kku.ac.kr.
4
Department of Biomedical Laboratory Science, College of Applied Science and Industry, Daejeon University, Daejeon 300-716, Korea. syhwang@dju.kr.
5
Department of Bioscience and Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Korea. funymans@naver.com.
6
Department of Integrated Biosciences, College of Biomedical & Health Science, Konkuk University, Chungju 27381, Korea. koppula@kku.ac.kr.
7
Department of Integrated Biosciences, College of Biomedical & Health Science, Konkuk University, Chungju 27381, Korea. skkim@kku.ac.kr.

Abstract

Age-related male sexual dysfunction covers a wide variety of issues, together with spermatogenic and testicular impairment. In the present work, the effects of cordycepin (COR), an active constituent of a nutrient powerhouse Cordyceps militaris Linn, on senile testicular dysfunction in rats was investigated. The sperm kinematics, antioxidant enzymes, spermatogenic factors, sex hormone receptors, histone deacetylating sirtuin 1 (SIRT1), and autophagy-related mammalian target of rapamycin complex 1 (mTORC1) expression in aged rat testes were evaluated. Sprague Dawley rats were divided into young control (2-month-old; YC), aged control (12-month-old; AC), and aged plus COR-treated groups (5 (COR-5), 10 (COR-10), and 20 (COR-20) mg/kg). The AC group showed reduced sperm kinematics and altered testicular histomorphology compared with the YC group (p < 0.05). However, compared with the AC group, the COR-treated group exhibited improved sperm motility, progressiveness, and average path/straight line velocity (p < 0.05-0.01). Alterations in spermatogenesis-related protein and mRNA expression were significantly ameliorated (p < 0.05) in the COR-20 group compared with the AC group. The altered histone deacetylating SIRT1 and autophagy-related mTORC1 molecular expression in aged rats were restored in the COR-20 group (p < 0.05). In conclusion, the results suggest that COR holds immense nutritional potential and therapeutic value in ameliorating age-related male sexual dysfunctions.

KEYWORDS:

Cordycepin; SIRT1; antioxidant; mTORC1; sex hormone receptors; spermatogenesis

PMID:
31018574
PMCID:
PMC6520895
DOI:
10.3390/nu11040906
[Indexed for MEDLINE]
Free PMC Article

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