Format

Send to

Choose Destination
Int J Environ Res Public Health. 2019 Apr 22;16(8). pii: E1429. doi: 10.3390/ijerph16081429.

Time to Onset of Paresthesia Among Community Members Exposed to the World Trade Center Disaster.

Author information

1
Department of Neurology, New York University School of Medicine, New York, NY 10017, USA. sujata.thawani@nyulangone.org.
2
Department of Population Health, New York University School of Medicine, New York, NY 10016, USA. bin.wang@nyulangone.org.
3
Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA. bin.wang@nyulangone.org.
4
Department of Population Health, New York University School of Medicine, New York, NY 10016, USA. yongzhao.shao@nyulangone.org.
5
Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA. yongzhao.shao@nyulangone.org.
6
Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA. joan.reibman@bellevue.nychhc.org.
7
Department of Medicine, New York University School of Medicine, New York, NY 10016, USA. joan.reibman@bellevue.nychhc.org.
8
Department of Neurology, New York University School of Medicine, New York, NY 10017, USA. michael.marmor@nyulangone.org.
9
Department of Population Health, New York University School of Medicine, New York, NY 10016, USA. michael.marmor@nyulangone.org.

Abstract

We examined whether time to onset of paresthesia was associated with indicators of severity of World Trade Center (WTC) exposure. We analyzed data from 3411 patients from the Bellevue Hospital-WTC Environmental Health Center. Paresthesia was defined as present if the symptom occurred in the lower extremities with frequency "often" or "almost continuous." We plotted hazard functions and used the log-rank test to compare time to onset of paresthesia between different exposure groups. We also used Cox regression analysis to examine risk factors for time-to-paresthesia after 9/11/2001 and calculate hazard ratios adjusted for potential confounders. We found significantly elevated hazard ratios for paresthesia for (a) working in a job that required cleaning of WTC dust in the workplace; and (b) being heavily exposed to WTC dust on September 11, 2001, after adjusting for age, race/ethnicity, depression, anxiety, post-traumatic stress disorder, and body mass index. These observational data are consistent with the hypothesis that exposure to WTC dust or some other aspect of cleaning WTC dust in the workplace, is associated with neuropathy and paresthesia. Further neurological evaluations of this and other WTC-exposed populations is warranted.

KEYWORDS:

Cox regression; World Trade Center exposure; hazard function; neuropathic symptoms; paresthesia

PMID:
31013580
DOI:
10.3390/ijerph16081429
Free full text

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI)
Loading ...
Support Center