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Artif Organs. 2019 Apr 23. doi: 10.1111/aor.13474. [Epub ahead of print]

Graphene Oxide Incorporated Polycaprolactone/Chitosan/Collagen Electrospun Scaffold: Enhanced Osteogenic Properties for Bone Tissue Engineering.

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National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
Tissues and Biomaterials Research Group (TBRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Department of Biomedical Engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran.
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran.
Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.


This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% graphene oxide (GO). Using standard tests and MG-63 cells the characteristics of scaffolds were evaluated, and the behavior of osteoblasts were simulated respectively. A non-significant decrease of nanofibers diameter was noted in scaffolds with a higher ratio of GO. The hydrophilicity and bioactivity of the scaffolds surface, as well as cell attachment and proliferation, increased in correspondence to an increase of GO. The higher ratio of GO also improved the osteogenesis activity. GO increased the degradation rate, but it was negligible and seemed not enough to endanger stability. Modifying the scaffolds with GO could not make a significant change to the antibacterial effect. This article is protected by copyright. All rights reserved.


Chitosan; Collagen; Electrospinning; Graphene oxide; Guided bone regeneration; Osteogenic property; Polycaprolactone


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