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PLoS One. 2019 Apr 23;14(4):e0215750. doi: 10.1371/journal.pone.0215750. eCollection 2019.

Ultrasonography and electrophysiological study of median nerve in patients with essential tremor.

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Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Neurology, Mediplex Sejong Hospital, Incheon, Korea.


Essential tremor (ET) is a common movement disorder characterized by postural or kinetic tremor. We aimed to evaluate median nerve enlargement in patients with ET using ultrasonography (USG). Thirty-eight hands from 19 patients with ET and 24 hands from 13 controls underwent nerve conduction studies (NCS) and USG at the wrist. Tremor severity was measured using the Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS). The median nerve cross sectional area (mCSA) in USG and NCS parameters were compared using ANCOVA. We evaluated the correlation between mCSA and NCS parameters or FTM-TRS scores using linear regression analysis. mCSA was significantly larger (p<0.001) and NCS parameters were different in two groups. Also, mCSA was negatively correlated with part B and C scores of FTM-TRS (p<0.001 and p = 0.039, respectively). In conclusion, median nerve enlargement with the changes of NCS parameters was observed and correlated with the severity of tremor in patients with ET.

Conflict of interest statement

The authors have declared that no competing interests exist.

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