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J Bacteriol. 2019 Jul 10;201(15). pii: e00091-19. doi: 10.1128/JB.00091-19. Print 2019 Aug 1.

Understanding the Genetic Code.

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Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California, USA


The universal triple-nucleotide genetic code is often viewed as a given, randomly selected through evolution. However, as summarized in this article, many observations and deductions within structural and thermodynamic frameworks help to explain the forces that must have shaped the code during the early evolution of life on Earth.


Genetic code

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