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Biomacromolecules. 2019 May 13;20(5):2058-2067. doi: 10.1021/acs.biomac.9b00267. Epub 2019 Apr 30.

Fish Collagen and Hydroxyapatite Reinforced Poly(lactide- co-glycolide) Fibrous Membrane for Guided Bone Regeneration.

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Research Center for Nano-Biomaterials, Analytical and Testing Center , Sichuan University , Chengdu 610064 , China.
State Key Laboratory of Oral Diseases , West China Hospital of Stomatology, Sichuan University , Chengdu 610065 , China.
Department of Biomaterials , Radboud University Medical Center , P.O. Box 9101 , 6500 HB , Nijmegen , The Netherlands.


The purpose of this study was to fabricate a low-immunogenicity fish collagen (FC) and bioactive nanohydroxyapatite (n-HA) enhanced poly(lactide- co-glycolide) (PLGA) nanofibrous membrane for guided bone regeneration (GBR) via electrospinning. The physicochemical properties and morphology study revealed that FC and n-HA particles were homogeneously dispersed in the PLGA fibrous matrix. Notably, the formation of enhanced polymeric chain network due to the interaction between FC and PLGA significantly improved the tensile strength of the PLGA membrane. The incorporation of FC altered the degradation behavior of fibers and accelerated the degradation rate of the PLGA-based membranes. Moreover, the membranes exhibited favorable cytocompatibility with bone mesenchymal stem cells (BMSCs) and human gingiva fibroblasts (HGF) cells. More importantly, the optimized membrane satisfied the requirements of the 'Biological evaluation of medical devices' during the incipient biosafety evaluation. All the results indicate that this composite fibrous membrane exhibits significant potential for guided bone or tissue regeneration.


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