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Tissue Eng Part C Methods. 2019 Jun;25(6):334-343. doi: 10.1089/ten.TEC.2018.0318.

Fully Three-Dimensional Bioprinted Skin Equivalent Constructs with Validated Morphology and Barrier Function.

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1 Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.
2 Department of Electrical and Computer Engineering, Bethlehem, Pennsylvania.
3 National Eye Institute, National Institutes of Health, Rockville, Maryland.
4 Department of Bioengineering, Lehigh University, Bethlehem, Pennsylvania.


This article describes a method for the biofabrication of skin tissue equivalents in a multiwell plate format. The technique and results overcome shortcomings of previously published engineering methods, and show good architecture and barrier function from well to well; thus it may be used for compound functional testing and for the development of disease tissue models for screening.


barrier function; bioprinting; high-throughput screening; keratinocytes; skin

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