Format

Send to

Choose Destination
Nutrients. 2019 Apr 18;11(4). pii: E876. doi: 10.3390/nu11040876.

Imbalance between Omega-6 and Omega-3 Polyunsaturated Fatty Acids in Early Pregnancy Is Predictive of Postpartum Depression in a Belgian Cohort.

Author information

1
Department of Public Health, University of Liège, 4000 Liège, Belgium. axelle.hoge@uliege.be.
2
Department of Public Health, University of Liège, 4000 Liège, Belgium. valentine.tabar@gmail.com.
3
Department of Public Health, University of Liège, 4000 Liège, Belgium. afdonneau@uliege.be.
4
Department of Public Health, University of Liège, 4000 Liège, Belgium. ndardenne@uliege.be.
5
Department of Obstetrics and Gynecology, CHR Citadelle Hospital, University of Liège, 4000 Liège, Belgium. docteurdegee@gmail.com.
6
Department of Obstetrics and Gynecology, CHR Citadelle Hospital, University of Liège, 4000 Liège, Belgium. marie.timmermans@chu.ulg.ac.be.
7
Department of Obstetrics and Gynecology, CHR Citadelle Hospital, University of Liège, 4000 Liège, Belgium. michelle.nisolle@uliege.be.
8
Department of Public Health, University of Liège, 4000 Liège, Belgium. mguillaume@uliege.be.
9
Metastasis Research Laboratory, GIGA-CANCER, University of Liège, 4000 Liège, Belgium. vcastronovo@uliege.be.

Abstract

While studies revealed that the omega-3 polyunsaturated fatty acids (n-3 PUFA) and their mediators would be able to regulate several biological processes involved into the development of postpartum depression (PPD), evidence from observational studies remains mixed. The aim of the present study was to investigate the association between maternal erythrocyte n-3 PUFA, measured in early pregnancy, and the risk of PPD. A Belgian cohort of 72 healthy women was screened. Erythrocyte fatty acids were analysed using gas chromatography. PPD was assessed using the Bromley Postnatal Depression Scale by phone interview one year after delivery. We observed a significant negative association between docosahexaenoic acid (DHA) levels and the risk of postpartum depression in the adjusted model (p = 0.034). Higher n-6/n-3 and arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratios were significantly associated with an increased odds of PPD (p = 0.013 and p = 0.043, respectively). Women with an omega-3 index <5% had a 5-fold increased risk of depressive episode than did those with an omega-3 index ≥5% (OR 5.22 (95%CI 1.24-21.88)). A low n-3 PUFA status, alone and combined with high n-6 PUFA status, in early pregnancy was associated with a greater risk of PPD. Management of maternal n-3 PUFA deficiency can be a simple, safe and cost-effective strategy for the prevention of this major public health issue.

KEYWORDS:

erythrocyte; polyunsaturated fatty acids; postpartum depression; pregnancy

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center