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Cell. 2019 Apr 18;177(3):516-518. doi: 10.1016/j.cell.2019.04.002.

Hear Pancreatic Cancer Stem Cells ROR.

Author information

1
Department of Translational Molecular Pathology and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. Electronic address: wyao22@mdanderson.org.
2
Department of Translational Molecular Pathology and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

Abstract

In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.

PMID:
31002791
DOI:
10.1016/j.cell.2019.04.002

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