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Cancer Genet Cytogenet. 1987 Mar;25(1):169-74.

Neurofibromatosis in a man with a ring 22: in situ hybridization studies.

Abstract

In situ hybridization with a c-sis probe was performed on peripheral lymphocytes of a man with neurofibromatosis and a ring 22 chromosome. Hybridization was observed on both the normal #22 and the ring 22, indicating that the patient is not constitutionally hemizygous for c-sis. The implications of a ring 22 constitution and the neurofibromatosis phenotype are discussed.

PMID:
3100017
[PubMed - indexed for MEDLINE]
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