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Medicina (Kaunas). 2019 Apr 17;55(4). pii: E110. doi: 10.3390/medicina55040110.

Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective.

Author information

1
Endocrinology Unit, Department of Medicine, University of Padova, via Ospedale 105, 35128 Padova, Italy. raffaele.pezzani@gmail.com.
2
AIROB-Associazione Italiana per la Ricerca Oncologica di Base, 3520128 Padova, Italy. raffaele.pezzani@gmail.com.
3
Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran. bahar.salehi007@gmail.com.
4
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy. sara.vitalini@unimi.it.
5
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy. marcello.iriti@unimi.it.
6
Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepcion 4070386, Chile. fzuniga@udec.cl.
7
Food Safety Research Center (Salt), Semnan University of Medical Sciences, Semnan 3519899951, Iran. javad.sharifirad@gmail.com.
8
Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepción, Concepcion 4070386, Chile. martorellpons@gmail.com.
9
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. ncmartins@med.up.pt.
10
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal. ncmartins@med.up.pt.

Abstract

Synergy is a process in which some substances cooperate to reach a combined effect that is greater than the sum of their separate effects. It can be considered a natural "straight" strategy which has evolved by nature to obtain more efficacy at low cost. In this regard, synergistic effects may be observed in the interaction between herbal products and conventional drugs or biochemical compounds. It is important to identify and exploit these interactions since any improvement brought by such kind of process can be advantageously used to treat human disorders. Even in a complex disease such as cancer, positive synergistic plant-drug interactions should be investigated to achieve the best outcomes, including providing a greater benefit to patients or avoiding adverse side effects. This review analyzes and summarizes the current knowledge on the synergistic effects of plant-drug interactions with a focus on anticancer strategies.

KEYWORDS:

anticancer; conventional chemotherapeutic agents; plant derivatives; plant-drug interaction; synergistic effects; synergy

PMID:
30999703
PMCID:
PMC6524059
DOI:
10.3390/medicina55040110
[Indexed for MEDLINE]
Free PMC Article

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