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Curr Opin Neurobiol. 2019 Apr 15;56:185-193. doi: 10.1016/j.conb.2019.03.004. [Epub ahead of print]

Principles of progenitor temporal patterning in the developing invertebrate and vertebrate nervous system.

Author information

1
Department of Basic Neurosciences, University of Geneva, Switzerland.
2
Department of Basic Neurosciences, University of Geneva, Switzerland; GIGA-Neurosciences, University of Liège, C.H.U. Sart-Tilman, Liège, Belgium.
3
Department of Basic Neurosciences, University of Geneva, Switzerland; Department of Neurology, Geneva University Hospital, Geneva, Switzerland. Electronic address: denis.jabaudon@unige.ch.

Abstract

During the development of the central nervous system, progenitors successively generate distinct types of neurons which assemble into the circuits that underlie our ability to interact with the environment. Spatial and temporal patterning mechanisms are partially evolutionarily conserved processes that allow generation of neuronal diversity from a limited set of progenitors. Here, we review examples of temporal patterning in neuronal progenitors in the Drosophila ventral nerve cord and in the mammalian cerebral cortex. We discuss cell-autonomous mechanisms and environmental influences on the temporal transitions of neuronal progenitors. Identifying the principles controlling the temporal specification of progenitors across species, as highlighted here, may help understand the evolutionary constraints over brain circuit design and function.

PMID:
30999235
DOI:
10.1016/j.conb.2019.03.004

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