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Brain Behav Immun. 2019 Apr 15. pii: S0889-1591(18)31195-4. doi: 10.1016/j.bbi.2019.04.001. [Epub ahead of print]

The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials.

Author information

1
Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
2
Faculty of Health, University of Canberra, Bruce, ACT 2617, Australia; Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, Canberra, ACT 2617, Australia.
3
Centre for Rural Health, College of Health and Medicine, University of Tasmania, Launceston 7250, Tasmania, Australia.
4
Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, Canberra, ACT 2617, Australia.
5
NICM Health Research Institute, Western Sydney University, Campbelltown, NSW 2560, Australia; Division of Psychology and Mental Health, University of Manchester, Manchester M13 9PL, United Kingdom.
6
Faculty of Health, University of Canberra, Bruce, ACT 2617, Australia; Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, Canberra, ACT 2617, Australia; Australian National University Medical School, Australian National University, Canberra, ACT 2605, Australia.
7
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria 3216, Australia; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia; Department of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3050, Australia.
8
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria 3216, Australia.
9
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria 3216, Australia. Electronic address: wolf.marx@deakin.edu.au.

Abstract

Blueberries are rich in polyphenols that may be beneficial to cognitive performance and mood. The aim of this systematic review was to evaluate randomized controlled trials investigating the effects of blueberries and blueberry products on measures of cognition and mood. In total, eleven articles (that included 12 studies) were identified using freeze-dried blueberries (n = 9 studies), whole blueberries (n = 2) and blueberry concentrate (n = 1). These studies were conducted in children (n = 5), young adults (n = 1), and older people with either no known cognitive impairment (n = 4) or indicated cognitive impairment (n = 2). Eight studies reported blueberry consumption or supplementation at various doses and time lengths to improve measures of cognitive performance, particularly short- and long-term memory and spatial memory. For mood, one study reported significant between-group improvements in positive affect from blueberry products, whereas four studies reported no improvement. Low risk of bias were observed across all studies. Based on the current evidence, blueberries may improve some measures of cognitive performance. However, considerable differences in study design, dosages, and anthocyanin content hinder between-study comparison. The use of standardized blueberry interventions, consideration of placebo formulations, and consistently reported cognitive performance tools are recommended in future trials. PROSPERO registration no. CRD42018100888.

KEYWORDS:

Anthocyanins; Blueberry; Cognition; Flavonoid; Human; Intervention; Mood; Nutraceuticals; Polyphenol

PMID:
30999017
DOI:
10.1016/j.bbi.2019.04.001

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