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Small. 2019 May;15(21):e1901254. doi: 10.1002/smll.201901254. Epub 2019 Apr 17.

Responsive Porous Microcarriers With Controllable Oxygen Delivery for Wound Healing.

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State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Department of Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.


Microcarriers with oxygen-delivering capacity have attracted increasing interest in the field of tissue regeneration. Here, a kind of molybdenum disulfide quantum dots (MoS2 QDs) integrated responsive porous microcarriers with controllable oxygen-delivering ability for wound healing is presented. The specific gelatin methacryloyl (GelMa) porous microcarriers are derived from inverse opal microparticles which can be decorated with the oxygen-carrying protein hemoglobin. Because of their characteristic porous structure, interconnected nanochannels, and excellent biocompatibility, the resultant microcarriers could carry oxygen extensively and provide support for tissue repair physically and biologically. Besides, since the typical photothermal effect of 2D materials and their derived 2D QDs, the inverse opal particles integrated with MoS2 QDs are imparted with photo-responsive capacity, which makes them able to release oxygen photo-controllably. It is demonstrated that the designed microcarriers can promote the repair of abdominal wall defects effectively with their multifunctional features. These remarkable properties point to the potential value of the microcarriers in wound healing and tissue engineering.


inverse opals; microcarrier; oxygen; tissue engineering; wound healing


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