Format

Send to

Choose Destination
Int Arch Occup Environ Health. 2019 Apr 15. doi: 10.1007/s00420-019-01433-4. [Epub ahead of print]

Risk of mesothelioma after cessation of asbestos exposure: a systematic review and meta-regression.

Author information

1
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1130, New York, NY, 10029, USA. paolo.boffetta@mssm.edu.
2
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. paolo.boffetta@mssm.edu.
3
Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.
4
Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
5
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
6
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Abstract

PURPOSE:

A 'risk reversal' has been observed for several human carcinogens following cessation of exposure, but it is unclear whether it also exists for asbestos-related mesothelioma.

METHODS:

We conducted a systematic review of the literature and identified nine studies that reported information on risk of mesothelioma after cessation of asbestos exposure, and performed a meta-regression based on random effects models. As comparison we analyzed results on lung cancer risk from four of these studies.

RESULTS:

A total of six risk estimates from five studies were included in the meta-analysis. The summary relative risk (RR) of mesothelioma for 10-year interval since cessation of exposure was 1.02 [95% confidence interval (CI) 0.87-1.19; p-heterogeneity 0.01]. The corresponding RR of lung cancer was 0.91 (95% CI 0.84-0.98).

CONCLUSIONS:

This analysis provides evidence that the risk of mesothelioma does not decrease after cessation of asbestos exposure, while lung cancer risk does.

KEYWORDS:

Asbestos; Mesothelioma; Time since last exposure

PMID:
30993422
DOI:
10.1007/s00420-019-01433-4

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center