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Digestion. 2019 Apr 16:1-9. doi: 10.1159/000497432. [Epub ahead of print]

Changes of Dyspeptic Symptom after Successful Eradication in Helicobacter pylori-Associated Dyspepsia.

Author information

1
Department of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
2
Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Japan, mkato1957@gmail.com.
3
Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan.
4
Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Japan.
5
Health Sciences University of Hokkaido, Tobetsu, Japan.

Abstract

BACKGROUND:

Helicobacter pylori (H. pylori) gastritis could cause dyspepsia, and eradication is recommended as the first-line treatment. Patients who continuously have their symptoms under control > 6 months after eradication are defined as having H. pylori-associated dyspepsia (HPD), whereas patients who do not benefit from successful eradication are defined as having functional dyspepsia.

OBJECTIVES:

We assessed changes in dyspeptic symptoms after successful eradication of H. pylori by using a questionnaire.

METHODS:

We studied H. pylori-infected dyspeptic participants with abdominal symptom scores > 4 points on the Global Overall Symptom (GOS) scoring items and received eradication therapy. We evaluated their symptoms using the GOS questionnaire before their eradications, at 1-month and at 1-year check-ups after eradication therapy.

RESULTS:

Thirty dyspeptic participants (mean age 59.6 ± 15.3 years) answered every questionnaire. Fourteen participants (46.7%) had HPD, whereas 16 participants (53.3%) were non-HPD patients. The questionnaire at 1 month showed sensitivity of 64.3% (9/14) and specificity of 56.3% (9/16) for HPD. Approximately 60% of H. pylori-infected dyspepsia participants were identified as having HPD or non-HPD within 1 month after their eradications.

CONCLUSIONS:

Approximately 60% of HPD participants improved at 1 month after eradication. The questionnaire at 1 month helped diagnose HPD in advance and guided next treatment choice.

KEYWORDS:

Eradication therapy; Functional dyspepsia; Functional gastrointestinal disorders; Global overall symptom; ROME IV

PMID:
30991388
DOI:
10.1159/000497432

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