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Depress Anxiety. 2019 Jun;36(6):533-542. doi: 10.1002/da.22898. Epub 2019 Apr 16.

The impact of attention deficit hyperactivity disorder in obsessive-compulsive disorder subjects.

Author information

1
Child and Adolescent Psychiatry Unit (UPIA), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.
2
Department od Psychiatry, Porto Alegre Health Science Federal University, Porto Alegre, Brazil.
3
Brazilian OCD Research Consortium (CTOC), Brazil.
4
Department of Psychiatry, Faculty of Medicine of Botucatu, State University of São Paulo, São Paulo, Brazil.
5
Psychiatry Institute, Department of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil.
6
Child Study Center, Yale University, New Haven, Connecticut.

Abstract

BACKGROUND:

Recent findings suggest an association between attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). Thus, we evaluated the clinical associated features of ADHD in a large sample of adult OCD patients.

METHODS:

A cross-sectional study including 955 adult patients with OCD from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (C-TOC). Clinical characteristics in adult OCD patients with and without comorbid ADHD were compared using Fisher's exact test, t-tests or Mann-Whitney tests. Bivariate analyses were followed by logistic regression analysis to identify clinical characteristics independently associated with ADHD comorbidity.

RESULTS:

The lifetime prevalence of ADHD in adult OCD patients was 13.7%. The current results indicate that OCD + ADHD patients were more severe, had an earlier onset of the obsessive-compulsive symptoms, a higher history of rheumatic fever, with higher frequencies of sensory phenomena and comorbidity with Tourette syndrome. They also had an increased risk for academic impairment and suicide attempts.

CONCLUSION:

Adult OCD patients with ADHD present some specific clinical features and may represent a special subgroup of adult OCD. Future studies should focus on the development of interventions more tailored to the phenotype of this subgroup of patients.

KEYWORDS:

attention deficit disorder with hyperactivity; comorbidity; obsessive-compulsive disorder

PMID:
30990937
DOI:
10.1002/da.22898

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