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Org Lett. 2019 Jun 7;21(11):3891-3894. doi: 10.1021/acs.orglett.9b00784. Epub 2019 Apr 16.

High Stability of a Donor-Acceptor Type Oxazepine-Containing Fluorophore and Its Applications in Cellular Imaging and Two-Photon Deep Tissue Imaging.

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Department of Chemistry, College of Natural Sciences , Seoul National University , Seoul 08826 , Republic of Korea.
Department of Chemistry , Korea University , Seoul 02841 , Republic of Korea.


A new donor (D)-acceptor (A) type naphthalene-based oxazepine-containing fluorophore, OXN-1, is reported, which shows unusually high stability in various environments. Its photophysical properties and structural stabilities under harsh conditions are thoroughly examined. The high stability of OXN-1 is explained by quantum chemical calculations. Its exceptional bioimaging capabilities for cells with low cytotoxicity are verified. In addition, its deep tissue imaging ability with two-photon microscopy (TPM) is evaluated.

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