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Spec Care Dentist. 2019 May;39(3):330-339. doi: 10.1111/scd.12378. Epub 2019 Apr 16.

Oral rehabilitation of a case with regional odontodysplasia using a regenerative approach-A case report and a review of literature.

Author information

1
Department of Oro-dental Genetics, Medical Research Centre of Excellency, National Research Centre, Cairo, Egypt.
2
Prosthodontic Department, Faculty of Dentistry, Misr International University, Cairo, Egypt.
3
Al-Azhar Cleft Lip and Palate Treatment Center, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.
4
Stem Cell Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, Egypt.

Abstract

AIM:

to investigate for the first time whether the regenerative approach can be used to rehabilitate a case with regional odontodysplasia (ROD). ROD is a rare, localized developmental anomaly of the dental tissues. Moreover, we review the various treatment protocols for ROD and compare them to the suggested regenerative protocol.

CASE REPORT:

A 22-year-old female patient diagnosed with ROD in the upper left quadrant was presented to our clinic. Initially, the affected teeth were extracted and three implants were inserted. A combination of autologous bone marrow mononuclear cells (BMMNCs) seeded on a collagen sponge, nanohydroxyapatite, and autologous platelet-rich fibrin (PRF) was used to enhance bone regeneration in the defective area and around the inserted implants. After 9 months, bone regeneration and successful osteointegration around the inserted implants were achieved, permitting the insertion of a fourth implant. After an additional six months, a final fixed restoration was constructed.

CONCLUSION:

The suggested regenerative approach provides a better treatment option for ROD patients to regenerate the lost bone, rehabilitate aesthetics, and restore normal function.

KEYWORDS:

bone marrow mononuclear cells; bone regeneration; platelet-rich fibrin; regional odontodysplasia

PMID:
30989685
DOI:
10.1111/scd.12378

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