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Aesthetic Plast Surg. 2019 Apr 15. doi: 10.1007/s00266-019-01373-x. [Epub ahead of print]

Comparative Evaluation of the Biodegradability and Wrinkle Reduction Efficacy of Human-Derived Collagen Filler and Hyaluronic Acid Filler.

Author information

1
Department of Dermatology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, 102 Heukseokro, Dongjak-gu, Seoul, 156-755, Republic of Korea.
2
Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.
3
Department of Dermatology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, 102 Heukseokro, Dongjak-gu, Seoul, 156-755, Republic of Korea. beomjoon@unitel.co.kr.
4
Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea. beomjoon@unitel.co.kr.

Abstract

BACKGROUND:

The development of fillers for wrinkle prevention is growing to meet rising demands to reduce the aging of skin.

OBJECTIVE:

In this experiment, we confirmed the effects of human collagen and hyaluronic acid filler biodegradation for wrinkle reduction using a photo-aging mouse model.

MATERIALS AND METHODS:

A total of 10 hairless mice (SKH1-Hrhr) were randomly divided into two groups and injected with hyaluronic acid and human-derived collagen filler. At 0, 2, 4, 8, and 12 weeks, PRIMOSlite®, folliscope, and MRI were used to evaluate the biodegradability of the fillers after the injections. We also studied the photo-aging mouse model for skin roughness and histological evaluation and confirmed that the filler injection had excellent anti-wrinkle effects.

RESULTS:

Human-derived collagen fillers had excellent biodegradability compared to that of hyaluronic acid fillers. The skin surface roughness in the photo-aging mouse models was significantly reduced after injections of human-derived collagen filler.

CONCLUSION:

Our results showed that the human-derived collagen filler had excellent biodegradability and effectively reduced wrinkle formation in a photo-aging mouse model.

NO LEVEL ASSIGNED:

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

KEYWORDS:

Collagen filler; Photo-aging; Ultraviolet; Wrinkle reduction

PMID:
30989276
DOI:
10.1007/s00266-019-01373-x

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