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Int J Nanomedicine. 2019 Mar 27;14:2145-2156. doi: 10.2147/IJN.S196050. eCollection 2019.

DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats.

Author information

1
Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, homeira_zardooz@sbmu.ac.ir.
2
Department of Research and Development, Sodour Ahrar Shargh Company, Tehran, Iran, mnazaran@nanochelatingtechnology.com.
3
Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, homeira_zardooz@sbmu.ac.ir.

Abstract

Aims:

Despite daily increase in diabetic patients in the world, currently approved medications for this disease, at best, only reduce its progression speed. Using novel technologies is a solution for synthetizing more efficient medicines. In the present study, we evaluated anti-diabetic effects of DIBc, a nano metal-organic framework, which is synthetized based on nanochelating technology.

Methods:

High-fat diet and streptozotocin-induced diabetic rats were treated by DIBc or metformin for 6 weeks.

Results:

DIBc decreased plasma glucose, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein compared with diabetic and metformin groups. In DIBc-treated rats, significant homeostasis model assessment of insulin resistance index, malondialdehyde, and tumor necrosis factor-α decrease was observed. H&E staining showed increased islet number and area in DIBc-treated rats compared with diabetic controls.

Conclusion:

The results showed anti-diabetic effects of nanochelating-based framework. So DIBc, as a nano structure, has the capacity to be evaluated in future studies as a novel anti-diabetic agent.

KEYWORDS:

DIBc; diabetes; high-fat diet; metal organic framework; nanochelating technology; streptozotocin

PMID:
30988614
PMCID:
PMC6443220
DOI:
10.2147/IJN.S196050
[Indexed for MEDLINE]
Free PMC Article

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