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Clin Exp Immunol. 1986 Jul;65(1):182-9.

Interleukin 2 enhances natural killing of varicella-zoster virus-infected targets.

Abstract

Preincubation of peripheral blood non-adherent mononuclear cells with purified or recombinant interleukin 2 (IL-2) significantly enhanced natural killer (NK) activity against uninfected and varicella-zoster virus (VZV)-infected targets, while antibody-dependent cellular cytotoxicity (ADCC) against VZV-infected targets was not increased. Preincubation of effector cells with IL-2 had no effect on conjugate formation, but lysis of both targets was increased in single cell assays. IL-2-enhanced NK against VZV-infected targets was independent of gamma-interferon (gamma-IFN) production.

PMID:
3098472
PMCID:
PMC1542273
[Indexed for MEDLINE]
Free PMC Article

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