Format

Send to

Choose Destination
Biomed Res. 2019;40(2):79-85. doi: 10.2220/biomedres.40.79.

Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes.

Author information

1
Laboratory of Histology and Cytology, Department of Anatomy, Hokkaido University Graduate School of Medicine.

Abstract

The vitreous of perinatal mice temporarily develops a unique vascular system, called the vasa hyaloidea propria (VHP). Observations showed the vessels possessed an extracellular matrix including the basement membrane in their entire length. Immunostaining of whole mount preparations of VHP with integrin β1 antibody displayed a bush-like network consisting of long and straight fibers which were associated with the VHP but extended apart from the blood vessels. Electron microscopically, each fiber was composed of a bundle of thin filaments different from collagen fibrils. Macrophages associated with the VHP appeared to be arrested by the integrin bushes. The integrin bushes fragmented and disappeared by postnatal day 10, just before the regression of the VHP. Macrophages were involved in the digestion and clearance of integrin bushes. The vitreous integrin bushes appear to provide a scaffold for architectural maintenance of the hyaloid vessels and macrophages.

PMID:
30982803
DOI:
10.2220/biomedres.40.79
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center