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Neurosci Biobehav Rev. 2019 Apr 10. pii: S0149-7634(18)30292-6. doi: 10.1016/j.neubiorev.2019.02.003. [Epub ahead of print]

Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders.

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School of Pharmacy and Biomedical Sciences, University of Central Lancashire, PR1 2XT, Preston, UK. Electronic address:
Department of Anatomy & Neurobiology, School of Medicine, University of California, Irvine, CA, 92617, USA. Electronic address:
Genetics of Cognition Laboratory, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova, Italy. Electronic address:
Neuroscience and Mental Health Research Institute (NMHRI), Division of Neuroscience, School of Biosciences, Cardiff University, CF24 4HQ, Cardiff, UK. Electronic address:


In this review we discuss the role of environmental and pharmacological treatments to enhance cognition with special regards to neurodevelopmental related disorders and aging. How the environment influences brain structure and function, and the interactions between rearing conditions and gene expression, are fundamental questions that are still poorly understood. We propose a model that can explain some of the discrepancies in findings for effects of environmental enrichment on outcome measures. Evidence of a direct causal correlation of nootropics and treatments that enhanced cognition also will be presented, and possible molecular mechanisms that include neurotrophin signaling and downstream pathways underlying these processes are discussed. Finally we review recent findings achieved with a wide set of behavioral and cognitive tasks that have translational validity to humans, and should be useful for future work on devising appropriate therapies. As will be discussed, the collective findings suggest that a combinational therapeutic approach of environmental enrichment and nootropics could be particularly successful for improving learning and memory in both developmental disorders and normal aging.


Cognitive impairment; Environmental enrichment; Neuro developmental disorders; Nootropics; Ras-ERK pathway

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