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Drug Discov Today. 2019 Apr 10. pii: S1359-6446(18)30538-5. doi: 10.1016/j.drudis.2019.04.006. [Epub ahead of print]

Expanding the activity spectrum of antiviral agents.

Author information

1
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway.
2
Institute of Technology, University of Tartu, Tartu 50090, Estonia.
3
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0027, Norway.
4
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Institute of Technology, University of Tartu, Tartu 50090, Estonia. Electronic address: denis.kainov@ntnu.no.

Abstract

Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs could reinforce the arsenal of available antiviral therapeutics pending the results of further pre-clinical and clinical studies.

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